Phospholipase A2-resistant liposomes

ABSTRACT

A method to inhibit phospholipase A2-type hydrolytic degradation of liposome membranes is disclosed comprising forming a liposome having a bilayer membrane comprising (i) between about 67.5-85 mol-% of a phospholipid of the formula:   &lt;IMAGE&gt;   and (ii) between about 15.0-32.5 mol-% of a lysophospholipid of the formula:   &lt;IMAGE&gt; wherein R1, R2 and R3 are individually (C10-C30) alkanoyl groups including from about 0-4 double bonds.



